EFFECT OF LOVASTATION IN THE TREATMENT OF PRIMARY HYPERCHOLESTEROLEMIA
S. Avdić, N. Pranjić, Z. Mujčinović, F. Hadžović, N. Suljaković,
B. Baraković and S. Pavljašević .
of Internal Disease, Institute of Occupational Health, Health
Centre Tuzla, Bosnia and Herzegovina
of inhibitors HMG-CoA reductase offers a new approach to treatment
of hypercholesterolemia. In this study total of 66 patients, saffering
of hypercholesterolemia included. They are divided in two groups
(35 patients with Lovastation treated and 31 without treatment).
All patients was undergo clinical examination and therapeutic
efficiency evaluated after 16 weeks (control per all 4 weeks).
There were no statistically significant difference noticed in
age, gender, tobaco consumptionand alcohol consumption and cholesterolemia
parameter levels in baseline measures between groups (p 0.05).
The partial corelation showed the statistically levels in the
Lovastation treated group (p 0.001). When testing duration of
therapy effect there appeared statistically significant difference
between two tested groups, in all parametres of hypercholesterolemia
(p 0.001). This maior reduction in LDL-C level and increase HDL-C
level by Lovastation therapy may be valuable for prevention of
CHR and the development of atherosclerosis. In the patients with