In three years of patients treatment long line (PICC) was used in 64 patients (41 boys). Leading diagnose was acute lymphatic leukosis (ALL) in 41 case, pretemporary delivery in 11 cases, congenital heart diseses (VCC) in 4 cases, patients after surgery in 5 cases and malnutrition in 1 case. The most frequent complication was obliteration of catheter in 10 cases, elevated body temperature in 5 cases (according to catheter sespsis criteria, sepsis was proved in only 1 case), bleeding in 3 cases, damageing of catheter in 2 cases, catheter flow out in 1 case. Average period of catheter use was 54 days and age of patients 1 day to 14 years. Conclusion: Application of long line (PICC) in treatment of pediatric patients, regarding undelying condition, was of greatest value. Complications like infectious complications and other (repeated vein punctions, pain etc.) were reduced. Approach to vein was simple and with great safety.