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Second Congress of Cardiology and Angiology of Bosnia & Herzegovina

 

PROSPECTIVELY OPENED CLINICAL-PHARMACOLOGICAL RESEARCH EFFICACY AND TOLERABILITY OF ONCE DAILY AMLODIPIN IN TREATMENT ANGINA PECTORIS STABILIS
E. Raljević1, I. Zulić2, V. Gerc1, M. Spužić1, A. Sudžuka1 and B. Begović2
Clinic for Heart Diseases and Rheumatism1, Clinical Center University of Sarajevo, Institute for pharmacology, clinical pharmacology and toxicology2, Sarajevo, Bosnia and Herzegovina

Objectives: In this prospectively randomized study we have examined the efficacy, tolerability, and safety antagonist of calcium channels, which is containing amlodipine its active component. Methods: After wash out phase of two weeks 20 patients of an average age 54,529+-8,74 (average +- STDEV), average weight 80 kg and average of duration of illness 3 years suffering from angina pectoris stabilis participated in the study. We controlled tolerate of exertion (exercise test - Bruce protocol), blood pressure, heart rate.We adjusted daily doses of amlodipine after every clinical axaminations (4 clinical axaminations in four months), recorded adverse effects of drugs and obtained specimens for laboratory testing.We didn't approved using any another antihypertensives and vazodilatators except oral hlortalidon and nitroglicerol in study period. Results: 17 patients finished study completely.After wash out phase average number of anginal attacks for all patients was 3,6+-1,8, average using of nitroglicerol in one week of wash-out phase was 3,8+-1,9, on last week of clinical examination average number of anginal attacks for all patinets was 1,4+-0,6, average using of nitroglicerol was 1,4+-0,63. We recorded good results in average of decreases blood pressure, heart rate and good tolerate of exercise test (Bruce protocol). Conclusion: This research has proved good tolerability of amlodipine with more than 85% of patients as well as its efficacy in decrease of anginal attacks, tolerate of exercise (Bruce protocol), lowering blood pressure and based on subjective estimation by patients, this drug improved life quality of all of them. .

Keywords: Amlodipin, Angina pectoris stabilis, Antianginal Agents, Antihypertensive, Agents, Bruce protocol, Electrocardiography, Exercise test, Human, Hypertension

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