MCoronary artery disease (CAD) is complex desease caused by interaction between genetic and enviromental factors.The main risc factors of CAD (hypertension, holesterol, diabetes, smoking) and their role in patogenesis of CAD are well examined and defined in numerous controled clinical sudies.Intensive development of molecular genetics in last decade has showed that the genetic polymorphism-mutation some of known gens, increase the risc of CAD.In our study we have analised correlation between polymorphism, insertion-deletion, of gene for angiotenzin convertising enzyme (ACE) and CAD in Bosnian population.Genetic polymorphism of components of renin-angiotenzin sistem is considered to be risc factor of CAD.In our study was included 100 patients with CAD from Cardiovascular Clinic Tuzla who were hospitalized in 1998-2000.Diagnosis of CAD was confirmed by coronary angiography.Control group has consisted from healty people and patients with some other cardiovascular disease.Molecular genetic diagnosis-detection has performed in Clinical Center Ljubljana by PCR (polymerase chain reaction) method.Statistical analysis has done and compared with data from literature