Introduction: The long acting calcium channel blockers and angiotensin converting enzyme (ACE) inhibitors are widely used as the combination therapy in patients with poor response on monotherapeutic regime. The purpose of this study is to evaluate the efficiacy and safety of amlodipine and lisinopril as the combination in therapy of essential hypertension.Calcium channel blockers are vasodilatatory agents with diuretic and natriuretic effect and tendency to increase plasma renin which provides evidence based for introducing ACE inhibitors in the combination.
Material and method: The open controlled clinical prospective study has been designed in the evalutionof the combination therapy.The lisinopril (lopril) 5 mg plus 5 mg amlodipine (amlodil) as the single dose were introduced initially with possibility to increase the dose if neccessary.The blood pressure and heart rate was recorded at baseline and at weekly interval for the analysis.Only monotherapy antihipertensive non-responders were included.
Results: These preliminary data suggest that this combination therapy is much more effective in lowering the blood pressure than monotherapy.The well controlled antyhypertensive effect have been observed.No serious side effects were noticed.
Discussion: The combination therapy of calcium channel blockers (amlodil) and ACE inhibitors (lopril) provide more effective results in comparation to individual medications in reducing blood pressure.Such combination has long acting effect on blood pressure and is more convinient than multiple dosing regime.