C-REACTIVE PROTEIN AS EARLY MARKER FOR CARDIOVASCULAR DISEASE
J. Čorić, E. Suljević and M. Panjeta
for Clinical Chemistry and Biochemistry, Sarajevo, Bosnia
We investigated effectiveness of the determination
C-reactive protein (CRP) as early marker for cardiovascular disease.
Quantitative determination the CRP is based on a immunaturbidimetry
technique on the Dade Behring Dimension RxL clinical chemistry
system. We have determined CRP values in 127 patients. Elevated
levels of CRP (>5 mg/L) were found in 43% patients with increased
concentracion of total cholesterol, tryglicerides and apolipoprotein
B and decreased concentracion of HDL-cholesterol and apolipoprotein
A. In 20 patients with myocardial infarction and increased CK-MB
activities were found levels of CRP about 5-6 times the upper
reference limit. Results shown that CPK may be early marker for
cardiovascular disease. High - sensitivity methods for CRP (RCRP)
measurement are needed for this purpose.