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Second Congress of Cardiology and Angiology of Bosnia & Herzegovina

 

CHURG - STRAUSS SYNDROME
A. Sofo-Hafizović, J. Džirlo-Todorović and S. Gornjaković
Hematology Clinic, Clinical Center University of Sarajevo, Bosnia and Herzegovina

H.M. male, 61 years old treated in January 2000. On the seventh day of his stay, besides febrile condition and fever during 24 hours, skin eruption of maculopapular rash with the clinical signs of cardiopulmonary deterioration. General condition of the patient is extremely dificult. He has had sinusitis from before and in 1995, he had diagnosis bronchial asthma. He was periodically treated with Salbutamol, Flutikazo, Salmetrol and kortikosteroids. Laboratory findings: sedimentation of erythrocites 80/136, leukocytes 28,3x109, eosinophyl 45%, albumin in serum 24,0 g/L, globulin in serum 42,0 g/L, IgG 29,6 g/L, IgE 890 IU/ml, immune complexes 6,5 mg/ml, positive krioglobulin, CD8 lymphocites positive, mass of erythrocites in urine. Radiograms indicate diffuse infiltrate changes in lung parenhim and oesophagi dysfunction, echo-sonography registered pericardial flow and increased echogenicity of kidney parenhim. After the following therapy: Predinosolonom and gamma globulin there was improvement in patient's condition. After 15 months, patient is well without previously mentioned symptoms and laboratory findings are within normal values. Churg-Strauss Syndrome represents a group necrotic vasculitis with affection of mid-size and small blood vessels. Alergic rinitis, sinusitis or bronchial asthma often come before this syndrome

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