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Second Congress of Cardiology and Angiology of Bosnia & Herzegovina

 

ASPIRIN THERAPY AND POSTOPERATIVE BLEEDING AFTER CORONARY ARTERY BAYPASS GRAFTING
E. Mujičić, M. Kulić, F. Kučukalić, S. Straus and E. Đonlić
Cardiac Surgery Clinic, Clinical Center University of Sarajevo, Bosnia and Herzegovina

Aspirin inhibits platelet function by blocking the synthesis of tromboxane A2, a vasoconstrictor and promoter of platelet aggregation. It exhibits its effect by inhibiting the cycloxygenase and hydroperoxidase reactions needed for the production of thromboxane A2. Platelets are unable to regenerate cycloxygenase and they show impaired aggregation for approximately seven days. Therefore patients treated with aspirin who will be undergoing CPB could face increased risk of postoperative bleeding. Method: This is a control study comparing tow groups of 10 patients. In one group patients stopped taking Aspirin more than seven days before the elective surgery and another group stopped taking aspirin less than seven days before the operation. All patients (males and females ageing between 40 and 70 years) in both groups had CAD, and they had coagulation tests within normal range before the operation. Conclusion: There was increased postoperative bleeding 12 hours after the operation in patients who had stopped taking aspirin less than one week before the operation (between 1 400 ml and 3 000 ml). In the group where Aspirin had been stopped more than one week before the CABG bleeding was between 400 and 900 ml, in first 12 hours following the operation .

Drugi kongres kardiologa i angiologa Bosne i Hercegovine
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