THERAPY AND POSTOPERATIVE BLEEDING AFTER CORONARY ARTERY BAYPASS
E. Mujičić, M. Kulić, F. Kučukalić, S. Straus and E. Đonlić
Surgery Clinic, Clinical Center University of Sarajevo, Bosnia
Aspirin inhibits platelet function by blocking
the synthesis of tromboxane A2, a vasoconstrictor and promoter
of platelet aggregation. It exhibits its effect by inhibiting
the cycloxygenase and hydroperoxidase reactions needed for the
production of thromboxane A2. Platelets are unable to regenerate
cycloxygenase and they show impaired aggregation for approximately
seven days. Therefore patients treated with aspirin who will be
undergoing CPB could face increased risk of postoperative bleeding.
Method: This is a control study comparing tow groups of 10 patients.
In one group patients stopped taking Aspirin more than seven days
before the elective surgery and another group stopped taking aspirin
less than seven days before the operation. All patients (males
and females ageing between 40 and 70 years) in both groups had
CAD, and they had coagulation tests within normal range before
the operation. Conclusion: There was increased postoperative bleeding
12 hours after the operation in patients who had stopped taking
aspirin less than one week before the operation (between 1 400
ml and 3 000 ml). In the group where Aspirin had been stopped
more than one week before the CABG bleeding was between 400 and
900 ml, in first 12 hours following the operation .